2010
Tile: Cerebellar loss and brain-stem atrophy associated with neonatal alloimmune thrombocytopenia in a discordant twin.
Author information: Mohila CA1, Kubicka ZJ, Ornvold KT, Harris BT.
1Department of Pathology, Dartmouth Medical School, One Medical Center Drive, DHMC, Lebanon, NH 03756, USA.
Title: Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review
Authors: MM Kamphuis,a N Paridaans,a L Porcelijn,b M De Haas,c CE van der Schoot,c A Brand,d GJ Bonsel,e, D Oepkes,a
a Department of Obstetrics, Leiden University Medical Centre, Leiden
b Sanquin Diagnostic Services, Amsterdam
c Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam
d Department of Immunohematology, Leiden University Medical Centre, Leiden e Department of Obstetrics and Prenatal Care, Erasmus Medical Centre, Rotterdam University, the Netherlands
Email d.oepkes@lumc.nl
TRALI
Title: Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies
Authors: Ulrich J. H. Sachs1, Wiebke Wasel1, Behnaz Bayat 1, Rainer M. Bohl 2, Katja Hattar 3, Heike Berghofer 1, Angelika Reil 4, Jurgen Bux 4, Gregor Bein 1 , Sentot Santoso,1 and Norbert Weissmann 5
1 Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
2 Institute of Pathology, University of the Saarland, Homburg/Saar, Germany
3 Medical Clinic V, University of Giessen Lung Center, Giessen, Germany
4 German Red Cross Blood Service West, Hagen, Germany
5 Excellence Cluster–Cardiopulmonary System (ECCPS), University of Giessen Lung Center, Giessen, Germany
Title: Reconsidering fetal and neonatal alloimmune thrombocytopia with a focus on screening and prevention.
Authors: Skogan B, Killie MK, Kieldsen-Kragh J, Ahlem MT, Tiller H, Stuge TB, Husebekk A.
Laboratory Medicene, University Hopital of North Norway N-9038 Tromso, Norway. bjornskogen@unn.no
Title: Neonatal alloimmune thrombocytopenia caused by an antibody specific for a newly identified allele of human platelet antigen-7.
Authors: Koh Y, Taniue A, Ishii H, Matsuyama N, Amakishi E, Hayashi T, Furuta RA, Fukumori Y, Hirayama F, Yoshimura K, Nagamine T, Tamai S, Nakano S.
Japanese Red Cross Osaka Blood Center and Yodogawa Christian Hospital, Osaka 536-8505, Japan.
Title: FNAIT: the fetus pleads guilty!
Author: Cécile Kaplan INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE, France.
Title: Antenatal treatment of fetal alloimmune thrombocytopenia: a current perspective.
Authors: Cheryl A. Vinograd, James B. Bussel
Division of Hematology, Department of Pediatrics, Weill Medical College of Cornell University, New York, NY, USA.
Title: Fetomaternal transfusion after amniocentesis and cordocentesis.
Authors: Sikovanyecz J, Horváth E, Pásztor N, Keresztúri A, Szabó J, Pál A.
Departments of Obstetrics and Gynecology, Faculty of Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Semmelweis u. 1., Szeged, 6725, Hungary.
Title: Fetal alloimmune thrombocytopenia: is less invasive antenatal management safe?
Authors: Mechoulan A, Kaplan C, Muller JY, Branger B, Philippe HJ, Oury JF, Ville Y, Winer N. Service de Gynécologie et Obstétrique, CHU, Nantes, 44093 Nantes, France.
Title: Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy
Pingguo Chen1,2,*, Conglei Li2,3,*, Sean Lang2,3, Guangheng Zhu2, Adili Reheman2, Christopher M. Spring2, John Freedman24, and Heyu Ni15
1. Canadian Blood Services, Toronto, Canada.
2. Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael’s Hospital, Toronto, ON; and Departments of 3Laboratory Medicine and Pathobiology, 4Medicine, and 5Physiology, University of Toronto, Toronto, ON
Some of the data from this manuscript were previously presented orally at the XXII Congress of the International Society of Thrombosis and Hemostasis, Boston, MA, July 13, 2009, and at The Platelets 2010 International Symposium in Ma’ale Hachamisha, Israel, May 17, 2010.
2011
Title: Clinical Applications of Platelet Antibody and Antigen Testing
Authors: Andrew J. Lochowicz, BS, Brian R. Curtis, PhD, MT(ASCP)SBB
Laboratory Medicine, Volume 42, Issue 11, November 2011, Pages 687–692, https://doi.org/10.1309/LMM242GKGHCKJRWI
Published: 01 November 2011
Title: Fetal and neonatal alloimmune thrombocytopenia: harvesting the evidence to develop a clinical approach to management.
Author information: Symington A1, Paes B.
1Hamilton Health Sciences, McMaster Children’s Hospital, Neonatal Division, McMaster University, Ontario, Canada.
Title: The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
Conglei Li,1,2 Siavash Piran,1,2 Pingguo Chen,2,3 Sean Lang,1,2,3 Alessandro Zarpellon,4 Joseph W. Jin,2,3 Guangheng Zhu,2 Adili Reheman,2 Dianne E. van der Wal,2 Elisa K. Simpson,1,2 Ran Ni,5 Peter L. Gross,5 Jerry Ware,6 Zaverio M. Ruggeri,4 John Freedman,1,2,7 and Heyu Ni1,2,3,7,8
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. 2Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada. 3Canadian Blood Services, Toronto, Ontario, Canada. 4Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. 5Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 6Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 7Department of Medicine and 8Department of Physiology, University of Toronto, Ontario, Canada.
Address correspondence to: Heyu Ni, Canadian Blood Services and Department of Laboratory Medicine and Pathobiology, St. Michael’s Hospital, University of Toronto, Room 420, LKSKI — Keenan Research Center, 209 Victoria Street, Toronto, Ontario, Canada M5B 1W8. Phone: ; Fax: 416.864.5826; E-mail: ac.hms@hin.
Title: Platelet antibodies and fetal growth: maternal antibodies against fetal platelet antigen 1a are strongly associated with reduced birthweight in boys.
Author information: Tiller H1, Killie MK, Husebekk A, Skogen B, Ni H, Kjeldsen-Kragh J, Øian P.
1Laboratory Medicine, Department of Obstetrics and Gynecology, University Hospital of North Norway, Tromsø, Norway.
Post Transfusion Purpura – PTP
Author: Edwin Massey
Clinical Guidelines and Policies from NHSBT, UK
INFORMATION INF153/1.1 Effective: 13/06/11
Title: New K103 β3 allele identified in a context of severe neonatal thrombocytopenia.
Authors: Jallu V, Bianchi F, Bertrand G, Kaplan C.
Platelet Immunology Laboratory, INTS, Paris, France.
Title: Role of kleihauer test in detection of fetomaternal haemorrhage (FMH) in women with reduced fetal movements
Authors: S Iftikhar, S Attarbashi, R El Gawly
Royal Elbert Edward Hospital, Wigan, UK
Title: Fetomaternal haemorrhage – an observational study
Authors: S Campbell, M O’Riordan
Cork University Maternity Hospital, Cork, Ireland
Title: Placental immunology and maternal alloimmune responses
Authors: Amanda Symington 1, Bosco Paes 2
1 Hamilton Health Sciences, McMaster Children’s Hospital (Neonatal Division), McMaster University, Hamilton, Ontario, Canada
2 Department of Pediatrics (Division of Neonatology), McMaster University, Hamilton, Ontario, Canada
Title: Fetal and neonatal alloimmune thrombocytopenia: prenatal interventions
Authors: Marije M. Kamphuis and Dick Oepkes
Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
Title: A review of pathophysiology and current treatment for neonatal alloimmune thrombocytopenia (NAIT) and introducing the Australian NAIT registry
Authors: Zoe K. MCQUILTEN,1,2 Erica M. WOOD,3,4 Helen SAVOIA 5 and Stephen COLE 6
1 Clinical fellow, Transfusion Medicine Services, Australian Red Cross Blood Service,
2 Department of Epidemiology and Preventive Medicine, Monash University,
3 Transfusion Medicine Specialist, Transfusion Medicine Services, Australian Red Cross Blood Service,
4 Department of Clinical Haematology, Faculty of Medicine, Nursing and Health Sciences, Monash University,
5 Consultant Haematologist, Department of Haematology, Royal Women’s Hospital, and 6 Maternal-Fetal Medicine Specialist, Royal Women’s Hospital, Melbourne, Australia.
Title: Noninvasive fetal genotyping of human platelet antigen-1a
Authors: PG Scheffer,a,b A Ait Soussan,a OJHM Verhagen,a GCML Page-Christiaens,b D Oepkes,c M de Haas,a CE van der Schoota
a Department of Experimental Immunohaematology, Sanquin Research Amsterdam and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
b Division of Perinatology and Gynaecology, University Medical Centre Utrecht, Utrecht, the Netherlands
c Department of Obstetrics, Leiden University Medical Centre, Leiden, the Netherlands
Correspondence: Dr CE van der Schoot, Sanquin Research Amsterdam, PO Box 9190, 1006 AD Amsterdam, the Netherlands. Email e.vanderschoot@sanquin.nl
Title: Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study.
Authors: Jeannette S von Lindern 1,2*†, Tjitske van den Bruele1,2†, Enrico Lopriore1 and Frans J Walther1
1 Division of Neonatology J6-S, Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
2 Department of Pediatrics, Groene Hart Hospital, Gouda, The Netherlands.
Title: Fetal and Neonatal Alloimmune Thrombocytopenia A Management Algorithm Based on Risk Stratification
Authors: Luis D. Pacheco, MD, Richard L. Berkowitz, MD, Kenneth J. Moise, Jr, MD, James B. Bussel, MD, Janice G. McFarland, MD, and George R. Saade, MD
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-0587, USA. ldpachec@utmb.edu
Title: The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: A UK national study using three data sources.
Authors: Knight M, Pierce M, Allen D, Kurinczuk JJ, Spark P, Roberts DJ, Murphy MF.
National Perinatal Epidemiology Unit, University of Oxford, Oxford. NHS Blood and Transplant Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Title: The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia
Authors: Stuge TB, Skogen B, Ahlen MT, Husebekk A, Urbaniek SJ, Bessos H.
Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway. tor.brynjar.stuge@uit.no
Title: Low-avidity anti-HPA-1a alloantibodies are capable of antigen-positive platelet destruction in the NOD/SCID mouse model of alloimmune thrombocytopenia.
Bakchoul T1, Kubiak S, Krautwurst A, Roderfeld M, Siebert HC, Bein G, Sachs UJ, Santoso S.
1Institute for Clinical Immunology and Transfusion Medicine, Medical Faculty, Justus Liebig University Giessen, Giessen, Germany.
2012
Title: The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes
Authors: Maria Therese Ahlen,1,2 Anne Husebekk,1,2 Mette Kjær Killie,1 Jens Kjeldsen-Kragh,3,4 Martin L. Olsson,5 and Bjørn Skogen1,2
1Department of Laboratory Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
2Department of Immunology, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
3Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullevål, 0407 Oslo, Norway
4Faculty Division Ullevål University Hospital, University of Oslo, 0407 Oslo, Norway
5Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, SE-221 00 Lund, Sweden
Title: Delayed diagnosis of fetal and neonatal alloimmune thrombocytopenia: a cause of perinatal mortality and morbidity.
Authors: Madani K1, Kamphuis MM, Lopriore E, Porcelijn L, Oepkes D.
1Department of Obstetrics Division of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands.
Title: Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
Conglei Li,1,2 June Li,1,2 Yan Li,2,3 Sean Lang,1,2,3 Issaka Yougbare,2 Guangheng Zhu,2 Pingguo Chen,2,3 and Heyu Ni1,2,3,4
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8
2Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada M5S 1A8
3Canadian Blood Services, Toronto, ON, Canada M5G 2M1
4Department of Medicine and Department of Physiology, University of Toronto, Toronto, ON, Canada M5S 1A8
Title: Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
Authors: Loewenthal R, Rosenberg N, Kalt R, Dardik R, Landau M, Yahalom V, Avishai O, Frenkel O, Gazit E, Steinberg DM, Lipitz S, Salomon O.
From the Tissue Typing Laboratory, the Fetal Medicine Unit Department of Obstetrics and Gynecology, and the Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel; the Department of Statistics and Operations Research, Raymond and Beverly Sackler Faculty of Exact Sciences, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and the National Blood Services Center, Tel Hashomer, Israel.
Title: Preimplantation genetic diagnosis for fetal neonatal alloimmune thrombocytopenia due to antihuman platelet antigen maternal antibodies.
Authors: Altarescu G, Eldar-Geva T, Grisaru-Granovsky S, Bonstein L, Miskin H, Varshver I, Margalioth EJ, Levy-Lahad E, Renbaum P.
Medical Genetics Institute, ZOHAR Preimplantation Genetic Diagnosis Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel. heona@szmc.org.il
Title: Recombinant Antibody for Treatment of Fetomaternal Alloimmune Thrombocytopenia
Dr Cedric Ghevaert
Contributing team members: Louise Hawkins, Nina Herbert, Paul Lloyd-Evans, Phil Cookson and Dr Lorna Williamson
Division of Transfusion Medicine, Department of Haematology, University of Cambridge, National Blood Service Center
UK 2009-12 – NHS Blood and Transplant, Research and Development Triennial Report 2009-12
Title: Would it be possible to prevent HPA-1a alloimmunization to reduce the incidence of fetal and neonatal alloimmune thrombocytopenia?
Author: Belinda M. Kumpel, PhD
Bristol Institute for Transfusion Sciences, NHS Blood and Transplant,Bristol, UK. e-mail: belinda.kumpel@nbs.nhs.uk
Title: Placental immunology and maternal alloimmune responses
B. M. Kumpel (1) & M. S. Manoussaka (2)
1 Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, Northway, Filton, Bristol, UK
2 Centre for Infection and Immunity, Division of Clinical Sciences, St George’s University of London, UK
Title: Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model.
Authors: Tiller H, Killie MK, Ohen P, Eksteen M, Husebekk A, Skogen B, Kjeldsen-Kragh J, Ni H.
From Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway; the Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael’s Hospital, and Canadian Blood Services, Toronto, Ontario, Canada; Division of Immunology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Immunology and Transfusion Medicine, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; the Departments of Laboratory Medicine and Pathobiology, Medicine, and Physiology, University of Toronto, Ontario, Canada.
Title: A Study of the HPA-1a Antibody Response in Neonatal Alloimmune Thrombocytopenia (NAIT)
Professor David Roberts
david.roberts@nhsbt.nhs.uk
Contributing team members: David Allen
NHS Blood and Transplant Triennial Report.2012
Title: Microfluidic approach to genotyping human platelet antigens.
Authors: Lim C, Manage DP, Atrazhev A, Denomme G, Backhouse CJ, Acker JP.
Canadian Blood Services, Research and Development, Edmonton, Canada.
Title: Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia.
Authors: Arinsburg SA, Shaz BH, Westhoff C, Cushing MM.
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Title: Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions
Juliana Vieira dos Santos BianchiI; Maria Regina Andrade de AzevedoII; Eduardo Jens I; Youko Nukui I; Dalton Alencar Ficher Chamone1
IHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo – USP, São Paulo, SP, Brazil
IIUniversidade Santo Amaro – UNISA, São Paulo, SP, Brazil
2013
Title: Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia
Authors: Ophira Salomon, Nurit Rosenberg
Correspondence: Professor Ophira Salomon, The Amalia Biron Research Institute of Thrombosis and Haemostasis, Sheba Medical Centre, Tel-Hashomer 52621, Israel.
E-mail: ophiras@sheba.health.gov.il
Title: Hemolysis After High Dose IVIG In Blood Group A Women With Alloimmune Thrombocytopenia
Karen Manotas, Jenny Jin, Cheryl Vinograd, Julia Gabor, Megan Wissert, Richard L. Berkowitz, Janice G McFarland, James B Bussel. Blood 2013 122:3540
Title: Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia
Tamam Bakchoul1,2, Andreas Greinacher1, Ulrich J. Sachs2, Annika Krautwurst2, Harald Renz3, Habi Harb3, Gregor Bein2, Peter J. Newman4, and Sentot Santoso2
1Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany;2Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany;3Institute for Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps Marburg University, Germany; and Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
Title: Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management
Authors: Peterson, J. A., McFarland, J. G., Curtis, B. R. and Aster, R. H. (2013)
British Journal of Haematology, 161: 3–14. doi: 10.1111/bjh.12235
Title: A Case of Alloimmune Thrombocytopenia, Hemorrhagic Anemia-Induced Fetal Hydrops, Maternal Mirror Syndrome, and Human Chorionic Gonadotropin–Induced Thyrotoxicosis
Authors: Venu Jain, MD, PhD,1 Gwen Clarke, MD,2 Laurie Russell, MD,2 Angela McBrien, MD,3 Lisa Hornberger, MD,3 Carmen Young, MD,1 and Sujata Chandra, MD1
1Division of Maternal-Fetal Medicine Royal Alexandra Hospital, University of Alberta, Edmonton, Alberta, Canada
2Department of Pathology and Laboratory Medicine, Royal Alexandra Hospital, University of Alberta, Edmonton, Alberta, Canada
3Division of Pediatric Cardiology/Fetal and Neonatal Cardiology Program, Royal Alexandra Hospital, University of Alberta, Edmonton, Alberta, Canada
Address for correspondence Venu Jain, MD, PhD Assistant Professor, 5S131 Lois Hole Hospital, Royal Alexandra Hospital, 10240 Kingsway Avenue, Edmonton, Alberta T5H 3V9, Canada,
Title: Fetal and Neonatal Alloimmune Thrombocytopenia
Authors: J P Espinoza, MD,1 J Caradeux, MD,1 Errol R Norwitz, MD, PhD,2 and S E Illanes, MD, MSc11Department of Obstetrics & Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de Los Andes,, Chile2Mother Infant Research Institute at Tufts Medical Center, Tufts University School of Medicine,, Boston, MA
Title: SCI-50 Fetal and Neonatal Alloimmune Thrombocytopenia: Lessons Learned from Animal Models
55th Annual Meeing and Exposition, New Orleans 7-10, 2013
Heyu Ni, MD, PhD. Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Department of Laboratory Medicine and Pathobiology, and Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada
Title: A V740L mutation in glycoprotein IIb defines a novel epitope (War) associated with fetomaternal alloimmune thrombocytopenia.
Author information: Poles A1, Woźniak MJ, Walser P, Ridgwell K, Fitzgerald J, Green A, Gilmore R, Lucas G.
1Histocompatibility and Immunogenetics, NHSBT, Bristol, United Kingdom; Bristol Institute for Transfusion Sciences, Bristol, United Kingdom; Irish Blood Transfusion Service, Dublin, Republic of Ireland; Galway University Hospital, Galway, Republic of Ireland.
REVIEW – Human platelet antigens – 2013 (To date, 33 human platelet alloantigens (HPAs) have been identified on six functionally important platelet glycoprotein (GP) complexes and have been implicated in alloimmune platelet disorders including foetal and neonatal alloimmunethrombocytopenia (FNAIT), posttransfusion purpura (PTP) and multitransfusionplatelet refractoriness (MPR)
B. R. Curtis & J. G. McFarland – Platelet & Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI, USA.
© 2013 International Society of Blood Transfusion DOI: 10.1111/vox.12085
Immuno Polymorphism Database
HPA Database
HPA Allele Frequencies
Robinson J, Halliwell JA, McWilliam H, Lopez R, Marsh SGE
IPD – the Immuno Polymorphism Database, Nucleic Acids Research (2013), 41: D1234-40
The European Bioinformatics Institute is part of EMBL, Europe’s flagship laboratory for the life sciences
We are a non-profit, intergovernmental organisation funded by EMBL member states. Our 500 staff represent 43 nationalities, and we welcome a regular stream of visiting scientists throughout the year. We are located on the Wellcome Genome Campus in Hinxton, Cambridge in the United Kingdom.
Title: Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry.
Heidi Tiller,1 Marije M Kamphuis,2 Olof Flodmark,3 Nikos Papadogiannakis,4 Anna L David,5 Susanna Sainio,6 Sinikka Koskinen,6 Kaija Javela,6 Agneta Taune Wikman,7 Riitta Kekomaki,6 Humphrey H H Kanhai,2 Dick Oepkes,2 Anne Husebekk,8 and Magnus Westgren9
1Department of Obstetrics and Gynaecology, University Hospital North Norway, Tromsø, Norway
2Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
3Neuroradiologiska kliniken, Karolinska Universitetssjukhuset, Stockholm, Sweden
4Department of Laboratory Medicine, Division of Pathology, Section of Perinatal Pathology, Karolinska Institutet, Stockholm, Sweden
5Obstetrics and Maternal Foetal Medicine, Institute for Women’s Health, University College, London, UK
6Finnish Red Cross Blood Service, Helsinki, Finland
7Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
8Institute of Medical Biology, University of Tromsø, Tromsø, Norway
9Department of Obstetrics and Gynaecology, Division of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Correspondence to Dr Magnus Westgren; Email: es.ik@nergtseW.sungaM
Human Platelet Antigen 1 Genotype – includes Table 1. A Couple’s Risk of Having a NAIT- affected offspring
Quest diagnostics, USA
Title: Prenatal Fetal DNA Testing for Predicting HDFN, FNAIT, and RhIG Candidacy
C. Ellen van der Schoot, MD, PhD1, Florentine Thurik, MD2, Peter G. Scheffer, MD, PhD3, Frithjofna Abbink, MSc4, van der Ploeg P.B. Catharina, PhD5, Barbera Veldhuisen, PhD6, and Masja de Haas, MD, PhD7
Author Affiliations: 1Sanquin Research Institute, Amsterdam, Netherlands, 2Sanquin Research Amsterdam, Amsterdam, Netherlands, 3Dept. of Gynaecology, St. Elisabeth Hospital, Tilburg, Netherlands, 4Centre for Population Screening, National Institute for Public Health and the Environment, Bilthoven, Netherlands, 5TNO-Child Health, Leiden, Netherlands, 6Sanquin Research, Amsterdam, Netherlands, 7Sanquin Diagnostic Services, Amsterdam, Netherlands
2014
Title: Incidence and Consequences of Neonatal Alloimmune Thrombocytopenia: A Systematic Review
Authors: Marije M. Kamphuis, MD; Noortje P. Paridaans, MD; Leendert Porcelijn, MD; Enrico Lopriore, MD; Dick Oepkes, MD.
Address for correspondence Marije M. Kamphuis, MD, Leiden University Medical Centre, Department of Obstetrics, K6-31, PO Box 9600, 2300 RC Leiden, the Netherlands. E-mail: m.m.kamphuis@lumc.nl
Title: Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention
Authors:Bjørn Skogen, Mette Kjær Killie, Jens Kjeldsen-Kragh, Maria Therese Ahlen, Heidi Tiller, Tor B Stuge & Anne Husebekk
Review title: Neonatal Alloimmune thrombocytopenia
Authors: Maria Teresa Mella, Keith A Eddleman
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai School of Medicine, New York, NY, USA
Open access
Title: Human platelet antigen (HPA)-1a peptides do not reliably suppress anti-HPA-1a responses using a humanized severe combined immunodeficiency (SCID) mouse model
Authors: D J Jackson, J L Eastlake, and B M Kumpel
1International Blood Group Reference Laboratory, Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, Bristol, UK
Correspondence: D. J. Jackson, International Blood Group Reference Laboratory, Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, 500 North Bristol Park, Bristol BS34 7QH, UK., E-mail:ku.shn.tbshn@noskcaj.evad
Title: Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants
Authors: Catherine A. Mazzola, M.D.1, Asim F. Choudhri, M.D.2,3, Kurtis I. Auguste, M.D.4, David D. Limbrick Jr., M.D., Ph.D.5, Marta Rogido, M.D.6,Laura Mitchell, M.A.7, and Ann Marie Flannery, M.D.8
1Division of Pediatric Neurological Surgery, Goryeb Children’s Hospital, Morristown, New Jersey; 2Departments of Radiology and Neurosurgery, University of Tennessee Health Science Center, and 3Le Bonheur Neuroscience Institute, Le Bonheur Children’s Hospital, Memphis, Tennessee; 4Department of Neurosurgery, University of California, San Francisco, California; 5Division of Pediatric Neurosurgery, St. Louis Children’s Hospital, St. Louis, Missouri; 6Division of Neonatology, Department of Pediatrics, Goryeb Children’s Hospital, Morristown; and Rutgers New Jersey Medical School, Newark, New Jersey; 7Congress of Neurological Surgeons, Schaumburg, Illinois; and 8Department of Neurological Surgery, Saint Louis University, St. Louis, Missouri
Title: Non-invasive Prenatal Testing for Chromosomal Abnormality using Maternal Plasma DNA
Published: 04/03/2014
This Scientific Impact Paper was produced on behalf of the Royal College of Obstetricians and Gynaecologists by: Professor PW Soothill FRCOG, Bristol and Professor YMD Lo FRCPath, FRS, Department of Chemical Pathology, The Chinese University of Hong Kong, China
Title: The role of alloantibodies against human platelet antigen-15 in multiply platelet transfused patients
Authors: Ika Matsuhashi,1,5 Nelson H. Tsuno,1 Shinji Sone,1 Yuko Mishima, 1 Yutaka Nagura,1 Naoko Watanabe-Okochi,1 Toshiyuki Ikeda,1 Koichi Kashiwase,3 Shinya Fukuda,4 Takayuki Iriyama,4 Hironobu Hyodo,4 Takahiro Yamashita,4 Yoshimasa Kamei,4 Shunya Arai,2 Mutsuhiko Minami,3 Tomoyuku Fujii,4 Mineo Kurokawa,2 Minoru Tozuka,5 Koki Takahashi,1 and Sentot Santoso 6.
Analytical Laboratory Chemistry, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Title: First Fetal Lung Maturity Test Based on Ultrasound Images
Eliminating the need to analyze amniotic fluid to determine the fetal lung maturity.
See links below:
quantusFLM is the First 100% Non-Invasive fetal lung maturity test Testimonials
quantusFLM Clinical Study.pdf
2015
Title: Antenatal diagnosis of intracranial haemorrhage and porencephalic cyst
Authors: T Williams1, A G Wilkinson2, J Kandasamy3, S Cooper1, J P Boardman4 Correspondence to Dr T Williams, thomascwilliams83@googlemail.com
http://dx.doi.org/10.1136/bcr-2014-209130
Title:Maternal anti-HLA class I antibodies are associated with reduced birthweight in thrombocytopenic neonates
Authors: J. Dahla, A. Husebekk, G. Acharyac, K. Floc, T.B. Stuge, B. Skogen, B.Straumed, H. Tiller
Title: 14 Years of Polish Experience in Non-Invasive Prenatal Blood Group Diagnosis
Authors: Agnieszka Orzinska, Katarzyna Guz, Marzena Debska, Małgorzata Uhrynowska, Zbigniew Celewicz, Mirosław Wielgoś, Ewa Brojer,
Title: Contemporary management of neonatal alloimmune thrombocytopenia: good outcomes in the intravenous immunoglobulin era: results from the Australian neonatal alloimmune thrombocytopenia registry
Authors: Gemma L. Crighton, Ri Scarborough, Zoe K. McQuilten, Louise E. Phillips, Helen F. Savoia, Bronwyn Williams, Rhonda Holdsworth, Amanda Henry, Erica M. Wood, Stephen A. Cole & On behalf of the Australian NAIT registry steering committee
Title: Anti-HLA Antibodies in Neonatal Alloimmune Thrombocytopenia – Is There Any Clinical Significance?
Authors: Lilach Bonstein, Nardeen Atweh, Nuhad Haddad, Yariv Fruchtman
Blood 2015 126:4647
Title: Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia
Authors: Issaka Yougbare, Tai Wei-she, Darko Zdravic, Pingguo Chen, Guangheng Zhu, Howard Leong-Poi, Qu Dawei, X. Lisa Yu, S. Adamson Lee, John Sled, Freedman John and Heyu Ni
Blood 2015 126:2254
Title: Alloantibody against new platelet alloantigen (Lapa ) on glycoprotein IIb is responsible for a case of fetal and neonatal alloimmune thrombocytopenia.
Authors: Wihadmadyatami H1,2, Heidinger K1, Röder L1, Werth S1, Giptner A1, Hackstein H1, Knorr M3, Bein G1, Sachs UJ1, Santoso S1.
1Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany.
2Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
3Department of Paediatric Oncology and Haematology, University Clinic, Essen, Germany.
Title: Pathogenesis of Anti-integrin αIIb-mediated Fetal and Neonatal Alloimmune Thrombocytopenia: Establishment of Novel Murine Models in αIIb Deficient and Human αIIb Transgenic Mice
A thesis submitted in conformity with the requirements for the degree of Master of Science, Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
Author: Brian Valdasz Advisor: Heyu Ni, University of Toronto, Canada.
Title: A simple genotyping procedure without DNA extraction to identify rare blood donors.
Authors: Silvy M1,2, Brès JC1, Grimaldi A2, Movia C2, Muriel V2, Roubinet F1, Chiaroni J1,2, Bailly P1,2.
1Établissement Français du Sang, Blood Cell Grand Sud, Montpellier-Marseille, France.
2UMR 7268 ADÉS Aix-Marseille Université-EFS-CNRS, Marseille, France.
Title: Noninvasive fetal genotyping of human platelet antigen-1a using targeted massively parallel sequencing.
Authors: Wienzek-Lischka S1, Krautwurst A1, Fröhner V1, Hackstein H1, Gattenlöhner S2, Bräuninger A2, Axt-Fliedner R3, Degenhardt J3, Deisting C3, Santoso S1, Sachs UJ1, Bein G1
1Institute for Clinical Immunology and Transfusion Medicine. 2Institute of Pathology. 3Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig-University, Giessen, Germany.
Title: A multicenter validation of recombinant β3 integrin–coupled beads to detect human platelet antigen-1 alloantibodies in 498 cases of fetomaternal alloimmune thrombocytopenia
Histocompatibility and Immunogenetics Laboratories, National Health Service Blood and Transplant (NHSBT), Colindale, London, UK.
Title: Neonatal Thrombocytopenia and Platelet Transfusion – A UK Perspective
Authors: Carr R.a · Kelly A.M.b · Williamson L.M.c
aDepartment of Haematology, Guy’s and St Thomas’ Hospital, King’s College London, London,
bDepartment of Haematology and Division of Transfusion Medicine, University of Cambridge, Cambridge, and cNHSBT, Watford, UK
Title: Review of Fetal and Neonatal Immune Cytopenias
Sharon Lewin, MD, and James B. Bussel, MD
The authors are affiliated with Weill Cornell Medical Center/New York Presbyterian Hospital in New York, New York. Dr Lewin is a clinical fellow in neonatology in the Division of Newborn Medicine in the Department of Pediatrics, and Dr Bussel is a professor of pediatrics and pediatrics in the Department of Obstetrics and Gynecology and in the Department of Medicine; he is also the director of the Platelet Research and Treatment Program in the Division of Pediatric Hematology and Oncology in the Department of Pediatrics
Title: Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia
Authors: Brian Vadasz, Pingguo Chen, Issaka Yougbaré, Darko Zdravic, June Li, Conglei Li, Naadiya Carrim
Title: Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
Authors: Issaka Yougbaré, Sean Lang, Hong Yang, Pingguo Chen, Xu Zhao, Wei-She Tai, Darko Zdravic, Brian Vadasz, Conglei Li, Siavash Piran, Alexandra Marshall, Guangheng Zhu, Heidi Tiller, Mette Kjaer Killie, Shelley Boyd, Howard Leong-Poi, Xiao-Yan Wen, Bjorn Skogen, S. Lee Adamson, John Freedman, and Heyu Ni
Title: Antenatal diagnosis of intracranial haemorrhage and porencephalic cyst
Authors: T Williams 1, A G Wilkinson 2, J Kandasmy 3, S Cooper 1, J P Boardman 4,
+ Author Affiliations
1Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
2Department of Radiology, Royal Hospital for Sick Children, Edinburgh, UK
3Department of Neurosurgery, Royal Hospital for Sick Children, Edinburgh, UK
4University of Edinburgh / MRC Centre for Reproductive Health, Edinburgh, UK
Correspondence to Dr T Williams, thomascwilliams83@googlemail.com
Title: True risk of fetal-neonatal alloimmune thrombocytopenia in subsequent pregnancies: a prospective observational follow-up study
Authors: H Tiller, A Husebekk, B Skogen,J Kjeldsen-Kragh, M Kjær.
Title: Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention
Author information: Brojer E1, Husebekk A2, Dębska M3, Uhrynowska M4, Guz K4, Orzińska A4, Dębski R3, Maślanka K4.
1Department of Immunohematology and Immunology of Transfusion Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland. ebrojer@ihit.waw.pl.
2Institute of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway.
32nd Department of Obstetrics and Gynecology, Medical Centre of Postgraduate Education, Warsaw, Poland.
4Department of Immunohematology and Immunology of Transfusion Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Title: Neonatal Alloimmune Thrombocytopenia
Roganović J1*, Kranjcec I2
1 Department of Pediatrics, Division of Hematology and Oncology, University Hospital Centre Rijeka, Croatia.
2 Division of Hematology and Oncology, Children’s Hospital Zagreb, Zagreb, Croatia.
*Corresponding Author: Jelena Roganović MD,Professor of Pediatrics, Pediatric Hematologist and Oncologist,
Department of Pediatrics, Division of Hematology and Oncology, University Hospital Centre Rijeka, Rijeka, 51000, Croatia.
E-mail: jelena.roganovic1@ri.t-com.hr
Clinically relevant to FNAIT
Title: 660 IgG Alloantibodies Against RBC Induced By Pregnancy or Transfusion Have Unique Glycosylation Patterns Which Correlate with Clinical Outcome of Hemolytic Disease of the Fetus or Newborn
Myrthe Elisabeth Sonneveld, MD1*, Rosina Plomp2*, Jon Admiraal1*, Carolien Koeleman2*, Agnes Hipgrave-Ederveen2*, Joke Koelewijn, PhD3*, Peter Ligthart3*, Masja De Haas, Prof, MD3*, Manfred Wuhrer, Prof2*, C. Ellen Van der Schoot, Prof, MD1 and Gestur Vidarsson, PhD1*
1Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands
2Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands
3Erythrocyte Serology, Sanquin Research, Amsterdam, Netherlands
Title: Missing link found between brain, immune system; major disease implications
University of Virginia School of Medicine Prof Jonathan Kipnis
Title: Effects of antepartum therapy for fetal alloimmune thrombocytopenia on maternal lifestyle
Authors: Karen Q. Rossi 1, K. Joy Lehman 2, and Richard W. O’Shaughnessy 1
1 Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, and 2 Department of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA
