2024

Title: Phase 2 Study on the Pharmacokinetics and Safety of RLYB212 in Pregnant Women at Higher Risk for HPA-1a Alloimmunization.
29 October 2024. Clinical Trial. Sponsor: Rallybio IPA, LLC.
The purpose of this Phase 2 study is to assess the pharmacokinetics (PK) and safety of RLYB212 in HPA-1b/b pregnant women at higher risk for HPA-1a alloimmunization and FNAIT.

Title: Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.
Published August 7, 2024. DOI: 10.1056/NEJMoa2314466 

Title: Placenta-associated biomarkers and pregnancy outcome in HPA-1a alloimmunization: A prospective cohort study.
Authors: Nora Hersoug Nedberg, Mona Nystad, Maria Therese Ahlen, Eirin Listau Bertelsen, Katarzyna Guz e, Małgorzata Uhrynowska, Marzena Dębska, Agnieszka Gierszon, Agnieszka Orzińska, Anne Husebekk, Ewa Brojer, Anne Cathrine Staff, heidi.tiller@uit.no 

Title: Perinatal and neurodevelopmental outcomes of fetal isolated ventriculomegaly: a systematic review and meta-analysis.
Authors: Fahimah Ali, Fiona Gurung, Surabhi Nanda, Spyros Bakalis, Srividhya Sankaran Tomoki Arichi, Kypros H. Nicolaides, Panicos Shangaris.

Title: Does absence of intracranial hemorrhage in the first pregnancy in fetal and neonatal alloimmune thrombocytopenia preclude occurrence in the second?
Authors: Katherine A. Knightly, James B. Bussel, Margaret McKelvy, Emilie Vander Haar.

Title: Generation of human antibodies targeting human platelet antigen (HPA)-1a
Janita J. Oosterhoff, Federica Linty, Remco Visser, Thijs de Vos, Suzanne Hofstede-van Egmond, Miranda van de Weerd, Leendert Porcelijn, Masja de Haas, Ellen van der Schoot, Gestur Vidarsson – Department of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.  https://doi.org/10.1111/trf.17758

Title: Does anti-HPA-1a affect birthweight in fetal and neonatal alloimmune thrombocytopenia?
Margaret McKelvy, Srishti Tyagi, Emilie Vander Haar, Madhavi Lakkaraja, Tim Tomy, Stacy Corke, Thea Palmer, Amihai Rottenstreich, Rick Kapur, Huiying Zhi, Debra Newman, Nina Scatz-Siemers, James Bussel.
First published: 11 January 2024. © Wiley Periodicals, LLC. Pediatric Blood & Cancer.
https://doi.org/10.1002/pbc.30835 

Title: Placental high-grade villitis and risk of developmental delay at one year.
Madeleine Caplan, Alexa Freedman, Lauren Keenan-Devlin, Matthew Pellerite, Linda Ernst, Gregory Miller, , Ann Borders.
CONCLUSION: These results suggest that the presence of high grade chronic villitis may be associated with risk of developmental delay in children born at and near term. The role of chronic placental inflammation and its effects on neurodevelopment should be investigated in a larger prospective cohort.