Other – links and information
Platelet antigen genotyping (the name of the blood test that is used to confirm a NAIT/FNAIT diagnosis)
USA
ARUP consult – A Physician’s Guide to Laboratory Test Selection and Interpretation
A web-based laboratory test selection tool that provides point-of-care diagnostic and interpretive information to clinicians and physicians
ARUP Laboratories is a national clinical and anatomic pathology reference laboratory and an enterprise of the University of Utah and its Department of Pathology. USA
Bloodworks Northwest (formerly Puget Sound Blood Center)
Platelet Antigen Genotyping test for NAIT (FNAIT) (NATP) USA click here
Platelet Immunology Laboratory
Headquarters: 921 Terry Avenue, Seattle, WA 98104
Blood Center of Wisconsin
Platelet Antigen Genotyping panel – tests
BloodCenter of Wisconsin Headquarters
638 N. 18th Street
Milwaukee, WI 53233
ISRAEL
Lilach Bonstein, PhD
Director of Blood Bank and Platelet Immunology laboratories
RAMBAM Healthcare Campus
Ha’aliyah St. 8, 31096 Haifa, Israel
Dr. Ariella Zivelin
Head of Coagulation Lab.
Sheba Medical Center
Laboratories Wing
Tel Hashomer 52621
Tel: +972-3-5302105
Fax: +972-3-5351568
________________________________________________________________________________
USA – Current ‘Algorithm’ for treatment by Professor James Bussel, New York. This is the gold standard used by many doctors in different countries in the absence of a definitive ‘protocol’.
Title: Fetal and Neonatal Alloimmune Thrombocytopenia A Management Algorithm Based on Risk Stratification
Authors: Luis D. Pacheco, MD, Richard L. Berkowitz, MD, Kenneth J. Moise, Jr, MD, James B. Bussel, MD, Janice G. McFarland, MD, and George R. Saade, MD
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-0587, USA. ldpachec@utmb.edu
UK – Platelet antigens and antibodies in Pregnancy This NHS Patient pamphlet gives a simple explanation of NAIT with diagrams – July 2014
Author: Geoff Lucas
Provides information on the diagnosis, laboratory investigation and clinical management of fetal/neonatal alloimmune thrombocytopenia (NAIT) for medical and scientific staff providing platelet immunology services within the National Health Service Blood and Transplant (NHSBT) Services.
NHS Blood and Transplant, Filton, North Bristol Park, Northway, Filton, Bristol BS34 7QH, UK
_________________________________________________________________________________
Transfusion related acute lung injury (TRALI)
http://hospital.blood.co.uk/library/pdf/INF271_3.pdf
Author: Dr Tom Latham
UK. NHSBT
http://bloodjournal.hematologylibrary.org/content/117/2/669.full.pdf
Title: Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies
Authors: Ulrich J. H. Sachs1, Wiebke Wasel1, Behnaz Bayat 1, Rainer M. Bohl 2, Katja Hattar 3, Heike Berghofer 1, Angelika Reil 4, Jurgen Bux 4, Gregor Bein 1 , Sentot Santoso,1 and Norbert Weissmann 5
1 Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
2 Institute of Pathology, University of the Saarland, Homburg/Saar, Germany
3 Medical Clinic V, University of Giessen Lung Center, Giessen, Germany
4 German Red Cross Blood Service West, Hagen, Germany
5 Excellence Cluster–Cardiopulmonary System (ECCPS), University of Giessen Lung Center, Giessen, Germany
_________________________________________________________________________________
Post transfusion purpura PTP
Information from the UK – Author: Edwin Massey
http://hospital.blood.co.uk/media/28095/inf153-post-transfusion-purpura.pdf
Information from the Australian Red Cross Service
_________________________________________________________________________________
http://www.ebi.ac.uk/ipd/hpa/table1.html
Platelet antigen table. All HPA – alloantigen/protein data
http://www.medprorx.com/forms/MedProRx_IVIg_chart.pdf
IVIG Brand Comparison Chart.
NOTE: This summary was prepared for use as a general educational tool, and is not intended for use as a clinical guideline. This information was obtained from a combination of manufacturer sources for the products listed herein; including product package inserts, promotional materials, as well as discussions with various medical affairs professionals. October, 2011.
http://www.ncbi.nlm.nih.gov/omim/173470#GeneStructure-173470
Gene structure.
http://www.medscape.com/viewarticle/436640_5
Intravenous Immunoglobulins: Viral Safety.
You will have to register with Medscape to view this. Registration is free.
PLASMA – What is plasma – frequently asked questions
Biotest Plasma Center – USA
Book. Title: Alloimmune Disorders of Pregnancy. Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn.
Edited by: Andrew G Hadley, International Blood Group Reference Library, Bristol, UK. Prof Peter Soothill, Department of Fetal and Maternal Medicine, St Michael’s Hospital, Bristol UK.
