2025
Title: 'A Study of Nipocalimab or Intravenous Immunoglobulin in Pregnancies at risk of Fetal and Neonatal Alloimmune Thrombocytopenia'
Author: ISRCTN - UK Clinical Study Registry. Prospectively registered date: 2024 - Recruitment status: Ongoing.
NCT06533098. https://doi.org/10.1186/ISRCTN17841362
Title: 'Double-blind, Randomized, Placebo-controlled Study Evaluating the Safety and Efficacy of Nipocalimab in Reducing the Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) in At-risk Pregnancies'
Author: Janssen Research & Development, LLC.
Brief summary: A Study of Nipocalimab in Reducing the Risk of Fetal and Alloimmune Thrombocytopenia (FNAIT) USA NCT6449651 80202135FNAIT3001 (FREESIA-1)
Title: 'Fetal–neonatal alloimmune thrombocytopenia: Mothers are affected too'
Authors: Eleanore A. McFarland, Emilie L. Vander Haar, Margaret H. McKelvy, Katherine A. Knightly, Stephanie V. Volpe, Thea D. Palmer, Stacy Corke, James B. Bussel
April 2025 https://doi.org/10.1111/bjh.20112
Title: Platelet transfusion before central venous line placement was significantly associated with bleeding events, while platelet count alone was not.
Author: Contributing Writer Megan Garlapow PhD.
May 2025 https://www.hematologyadvisor.com
Title: 'Increased frequency of autism by previous diagnosis and screening in children with fetal-neonatal alloimmune thrombocytopenia with and without an intracranial hemorrhage'
Authors: Eleanore A McFarland, Katherine A Knightly, Emilie Vander Haar, Margaret H McKelvy, Thea D Palmer, Stephanie V Volpe, Stacy Corke, James B Bussel
June 2025 https://doi.org/10.1016/j.ajog.2025.06.052
Title: 'HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins'
Authors: Janita J. Oosterhoff, Wendy Stam, Suze R. van Brummelen, Arthur E. H. Bentlage, Thijs de Vos, José María de Pereda, Leendert Porcelijn, Rick Kapur, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson, Coert Margadant
Oct 2025 https://doi.org/10.1182/blood.2025029618
Title: 'In pursuit of FNAIT biomarkers: αVβ3 specificity falls short'
Authors: Peter J. Newman, Debra K. Newman
This is a commentary to the above paper: HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins
October 2025 https://doi.org/10.1182/blood.2025030524

