Title: The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes
Authors: Maria Therese Ahlen,1,2 Anne Husebekk,1,2 Mette Kjær Killie,1 Jens Kjeldsen-Kragh,3,4 Martin L. Olsson,5 and Bjørn Skogen1,2
1Department of Laboratory Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
2Department of Immunology, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
3Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullevål, 0407 Oslo, Norway
4Faculty Division Ullevål University Hospital, University of Oslo, 0407 Oslo, Norway
5Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, SE-221 00 Lund, Sweden
Title: Delayed diagnosis of fetal and neonatal alloimmune thrombocytopenia: a cause of perinatal mortality and morbidity.
Authors: Madani K1, Kamphuis MM, Lopriore E, Porcelijn L, Oepkes D.
1Department of Obstetrics Division of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands.
Title: Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
Conglei Li,1,2 June Li,1,2 Yan Li,2,3 Sean Lang,1,2,3 Issaka Yougbare,2 Guangheng Zhu,2 Pingguo Chen,2,3 and Heyu Ni1,2,3,4
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8
2Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada M5S 1A8
3Canadian Blood Services, Toronto, ON, Canada M5G 2M1
4Department of Medicine and Department of Physiology, University of Toronto, Toronto, ON, Canada M5S 1A8
Title: Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
Authors: Loewenthal R, Rosenberg N, Kalt R, Dardik R, Landau M, Yahalom V, Avishai O, Frenkel O, Gazit E, Steinberg DM, Lipitz S, Salomon O.
From the Tissue Typing Laboratory, the Fetal Medicine Unit Department of Obstetrics and Gynecology, and the Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel; the Department of Statistics and Operations Research, Raymond and Beverly Sackler Faculty of Exact Sciences, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and the National Blood Services Center, Tel Hashomer, Israel.
Title: Preimplantation genetic diagnosis for fetal neonatal alloimmune thrombocytopenia due to antihuman platelet antigen maternal antibodies.
Authors: Altarescu G, Eldar-Geva T, Grisaru-Granovsky S, Bonstein L, Miskin H, Varshver I, Margalioth EJ, Levy-Lahad E, Renbaum P.
Medical Genetics Institute, ZOHAR Preimplantation Genetic Diagnosis Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem, Israel. email@example.com
Title: Recombinant Antibody for Treatment of Fetomaternal Alloimmune Thrombocytopenia
Dr Cedric Ghevaert
Contributing team members: Louise Hawkins, Nina Herbert, Paul Lloyd-Evans, Phil Cookson and Dr Lorna Williamson
Division of Transfusion Medicine, Department of Haematology, University of Cambridge, National Blood Service Center
UK 2009-12 – NHS Blood and Transplant, Research and Development Triennial Report 2009-12
Title: Would it be possible to prevent HPA-1a alloimmunization to reduce the incidence of fetal and neonatal alloimmune thrombocytopenia?
Author: Belinda M. Kumpel, PhD
Bristol Institute for Transfusion Sciences, NHS Blood and Transplant,Bristol, UK. e-mail: firstname.lastname@example.org
Title: Placental immunology and maternal alloimmune responses
B. M. Kumpel (1) & M. S. Manoussaka (2)
1 Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, Northway, Filton, Bristol, UK
2 Centre for Infection and Immunity, Division of Clinical Sciences, St George’s University of London, UK
Title: Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model.
Authors: Tiller H, Killie MK, Ohen P, Eksteen M, Husebekk A, Skogen B, Kjeldsen-Kragh J, Ni H.
From Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway; the Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael’s Hospital, and Canadian Blood Services, Toronto, Ontario, Canada; Division of Immunology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Immunology and Transfusion Medicine, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; the Departments of Laboratory Medicine and Pathobiology, Medicine, and Physiology, University of Toronto, Ontario, Canada.
Title: A Study of the HPA-1a Antibody Response in Neonatal Alloimmune Thrombocytopenia (NAIT)
Professor David Roberts
Contributing team members: David Allen
NHS Blood and Transplant Triennial Report.2012
Title: Microfluidic approach to genotyping human platelet antigens.
Authors: Lim C, Manage DP, Atrazhev A, Denomme G, Backhouse CJ, Acker JP.
Canadian Blood Services, Research and Development, Edmonton, Canada.
Title: Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia.
Authors: Arinsburg SA, Shaz BH, Westhoff C, Cushing MM.
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Title: Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions
Juliana Vieira dos Santos BianchiI; Maria Regina Andrade de AzevedoII; Eduardo Jens I; Youko Nukui I; Dalton Alencar Ficher Chamone1
IHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo – USP, São Paulo, SP, Brazil
IIUniversidade Santo Amaro – UNISA, São Paulo, SP, Brazil